Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Aging Knowl. Environ., 25 February 2004
Vol. 2004, Issue 8, p. pe8
[DOI: 10.1126/sageke.2004.8.pe8]

PERSPECTIVES

Is Akt the Mastermind Behind Age-Related Heart Disease?

Patrick Kaminker

The author is at the Buck Institute for Age Research, Novato, CA 94947, USA. E-mail: pkaminker{at}buckinstitute.org

http://sageke.sciencemag.org/cgi/content/full/2004/8/pe8

Key Words: Akt • endothelial cells • kinase • cardiovascular disease • insulin • insulin-like growth factor

Abstract: Over the past several years, the insulin/insulin-like growth factor (IGF) signaling pathway has become a central figure in the study of organismal aging. Mutations in components of this pathway have led to enhanced longevity in several organisms, but it is still not clear whether and how this pathway contributes to human aging and aging-related diseases. In a new study, Miyauchi and colleagues propose that Akt, a member of the phosphatidylinositol 3-kinase family and a downstream component of the insulin/IGF pathway, plays a central role in the life span of endothelial cells. These findings implicate the insulin/IGF pathway in the development and progression of cardiovascular disease.

Citation: P. Kaminker, Is Akt the Mastermind Behind Age-Related Heart Disease? Sci. Aging Knowl. Environ. 2004 (8), pe8 (2004).

Read the Full Text




THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Myocardial AKT: The Omnipresent Nexus.
M. A. Sussman, M. Volkers, K. Fischer, B. Bailey, C. T. Cottage, S. Din, N. Gude, D. Avitabile, R. Alvarez, B. Sundararaman, et al. (2011)
Physiol Rev 91, 1023-1070
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science of Aging Knowledge Environment. ISSN 1539-6150