Sci. Aging Knowl. Environ., 3 March 2004
Vol. 2004, Issue 9, p. pe9
[DOI: 10.1126/sageke.2004.9.pe9]


Regulation of Transcriptional Coactivator PGC-1{alpha}

Danielle Melloul, and Markus Stoffel

Danielle Melloul is in the Department of Endocrinology at Hadassah University Hospital, Jerusalem 91120, Israel. Markus Stoffel is in the Laboratory of Metabolic Diseases at Rockefeller University, New York, NY 10021, USA. E-mail: stoffel{at}

Key Words: nuclear receptor • metabolism • mitochondria • oxidative phosphorylation • type 2 diabetes

Abstract: Transcriptional coregulators modulate the activity of transcription factors and are required for the proper regulation of gene expression. One transcriptional coactivator, peroxisome proliferator-activated receptor-{gamma} coactivator 1{alpha} (PGC-1{alpha}), plays an important role in the control of energy metabolism and has been associated with type 2 diabetes. A recent paper by Fan et al. provides new information about the posttranslational regulation of PGC-1{alpha} activity. This Perspective discusses the implications of these findings with respect to diabetes and aging.

Citation: D. Melloul, M. Stoffel, Regulation of Transcriptional Coactivator PGC-1{alpha}. Sci. Aging Knowl. Environ. 2004 (9), pe9 (2004).

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