Sci. Aging Knowl. Environ., 30 March 2005
Vol. 2005, Issue 13, p. nf24
[DOI: 10.1126/sageke.2005.13.nf24]


Feeling Spunky With JNK

Protein funnels stress signals into insulin pathway and extends life

R. John Davenport

Abstract: Only a masochist would choose a life of stress and starvation, yet organisms can last unusually long if they exploit molecular pathways that respond to these pressures. Now, scientists reveal how one molecule connects two such pathways and lengthens the lives of worms and flies. The protein is linked to diabetes in mammals, suggesting that what benefits invertebrates might not be good for humans. Researchers need to probe deeper to understand how it shapes mammalian longevity, experts say.

Citation: R. J. Davenport, Feeling Spunky With JNK. Sci. Aging Knowl. Environ. 2005 (13), nf24 (2005).

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