Sci. Aging Knowl. Environ., 30 March 2005
Vol. 2005, Issue 13, p. nf25
[DOI: 10.1126/sageke.2005.13.nf25]


Mopping Up Nuclear Waste

Molecule helps dispose of damaged proteins in the cell's command center

Mitch Leslie

Abstract: A cell relies on molecular janitors to clear away trashed proteins, but researchers didn't know whether these cleanup crews tidied the nucleus. However, a new study identifies a housekeeping molecule that works in that structure, dispatching damaged proteins to the cell's refuse incinerator. The molecule may play a role in illnesses that involve protein buildup in the nucleus, such as Parkinson's disease.

Citation: M. Leslie, Mopping Up Nuclear Waste. Sci. Aging Knowl. Environ. 2005 (13), nf25 (2005).

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