Sci. Aging Knowl. Environ., 6 April 2005
Vol. 2005, Issue 14, p. dn1
[DOI: 10.1126/sageke.2005.14.dn1]

NEURODEGENERATIVE DISEASE CASE STUDIES

Dementia of the Alzheimer's Type and Accelerated Aging in Down Syndrome

D. A. Devenny, J. Wegiel, N. Schupf, E. Jenkins, W. Zigman, S. J. Krinsky-McHale, and W. P. Silverman

The authors are at the Departments of Psychology, Developmental Neurobiology, and Cytogenetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA; and the Gertrude Sergievsky Center, Columbia University, New York, NY, USA (N. S.). E-mail: dadevenny{at}aol.com

http://sageke.sciencemag.org/cgi/content/full/2005/14/dn1

Abstract: This case study, of a woman with Down syndrome and dementia of the Alzheimer's type (DAT), follows the course of her decline over an 11-year period until death at age 57. Detailed neuropathological findings are also presented. This case illustrates features of premature aging that are typically associated with Down syndrome, and the progressive changes in memory and cognition that are usually associated with DAT. Although the subject's cardiovascular condition and thyroid disorder were treated, they may have contributed to the decline of her memory. This case shows the difficulty in diagnosing dementia in an individual with mental retardation who suffered comorbid episodes of depression and psychosis.

Citation: D. A. Devenny, J. Wegiel, N. Schupf, E. Jenkins, W. Zigman, S. J. Krinsky-McHale, W. P. Silverman, Dementia of the Alzheimer's Type and Accelerated Aging in Down Syndrome. Sci. Aging Knowl. Environ. 2005 (14), dn1 (2005).

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