Sci. Aging Knowl. Environ., 13 April 2005
Vol. 2005, Issue 15, p. nf28
[DOI: 10.1126/sageke.2005.15.nf28]

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Inflaming Chronic Pain

Immune cells might trigger mysterious untreatable pain

Mitch Leslie

http://sageke.sciencemag.org/cgi/content/full/2005/15/nf28

Abstract: Certain molecules help immune cells recognize bacteria and viruses. But prodding one of these so-called receptors might help trigger a form of pain, neuropathy, that even powerful drugs can't quell, according to new research. The work shows that obliterating a Toll-like receptor in a type of immune cell that lurks in the nervous system alleviates the rodent version of this condition. The results might help researchers illuminate the pathway that torments many patients and tease out immune cells' role in pain.

Citation: M. Leslie, Inflaming Chronic Pain. Sci. Aging Knowl. Environ. 2005 (15), nf28 (2005).

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