Sci. Aging Knowl. Environ., 13 April 2005
Inflaming Chronic Pain
Immune cells might trigger mysterious untreatable pain
Abstract: Certain molecules help immune cells recognize bacteria and viruses. But prodding one of these so-called receptors might help trigger a form of pain, neuropathy, that even powerful drugs can't quell, according to new research. The work shows that obliterating a Toll-like receptor in a type of immune cell that lurks in the nervous system alleviates the rodent version of this condition. The results might help researchers illuminate the pathway that torments many patients and tease out immune cells' role in pain.
Citation: M. Leslie, Inflaming Chronic Pain. Sci. Aging Knowl. Environ. 2005 (15), nf28 (2005).
Science of Aging Knowledge Environment. ISSN 1539-6150