Sci. Aging Knowl. Environ., 20 April 2005
Vol. 2005, Issue 16, p. nf30
[DOI: 10.1126/sageke.2005.16.nf30]


Sins of Synuclein

Chemical attachments turn Parkinson's protein into cell killer

Mitch Leslie

Abstract: As any makeover expert will attest, the wrong accessories can spoil even the most stylish outfit. But when a brain protein implicated in Parkinson's disease (PD) dons an extra chemical group, the result is worse than a fashion faux pas. The protein becomes poisonous, according to new research. The work also stokes a controversy in the PD field by suggesting that the protein knots that infest brain cells of patients are helpful--not harmful, as many scientists argue.

Citation: M. Leslie, Sins of Synuclein. Sci. Aging Knowl. Environ. 2005 (16), nf30 (2005).

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