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Sci. Aging Knowl. Environ., 1 June 2005
Vol. 2005, Issue 22, p. nf40
[DOI: 10.1126/sageke.2005.22.nf40]


Ties That Bind the Brain

Parkin and glutathione deficits slay dopamine-producing neurons in flies

R. John Davenport

Abstract: To expose mob scams and shady corporations, investigators must make connections between key wrongdoers. Now, researchers have linked two perpetrators that contribute to Parkinson's disease (PD). A defect in an antioxidant system that doesn't by itself cause trouble for flies exacerbates neuron loss in insects with a PD-associated mutation. The findings suggest that PD arises when antioxidants can't counteract mounting protein damage.

Citation: R. J. Davenport, Ties That Bind the Brain. Sci. Aging Knowl. Environ. 2005 (22), nf40 (2005).

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