Sci. Aging Knowl. Environ., 29 June 2005
Vol. 2005, Issue 26, p. nf51
[DOI: 10.1126/sageke.2005.26.nf51]


Engine Trouble

Malfunctioning molecular motors hinder cleanup of damaged proteins

Mitch Leslie

Abstract: Like big-city garbage trucks, molecular transporters in cells have to keep moving or trash piles up, according to a new study. The work shows that faulty haulers stall the removal of contorted proteins like those that accumulate in brain illnesses such as Parkinson's disease and Alzheimer's disease. The results support the idea that spurring cells to tidy up might stave off brain deterioration.

Citation: M. Leslie, Engine Trouble. Sci. Aging Knowl. Environ. 2005 (26), nf51 (2005).

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Science of Aging Knowledge Environment. ISSN 1539-6150