Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Aging Knowl. Environ., 29 June 2005
Vol. 2005, Issue 26, p. pe20
[DOI: 10.1126/sageke.2005.26.pe20]

PERSPECTIVES

Reactive Oxygen Species and Aging: Evolving Questions

Laura L. Dugan, and Kevin L. Quick

The authors are in the Division of General Medicine and Geriatrics in the Department of Medicine at the University of California, San Diego, La Jolla, CA 92093, USA. E-mail: ladugan{at}ucsd.edu (L.L.D.)

http://sageke.sciencemag.org/cgi/content/full/2005/26/pe20

Key Words: reactive oxygen species • oxidative damage • mitochondria • superoxide dismutase mimetic • calorie restriction • Sir2

Abstract: Over the past 50 years, reactive oxygen species (ROS) have been investigated as putative mediators of the process of aging. As specific genes and pathways that are involved with ROS homeostasis have been linked to aging in lower organisms, such as Caenorhabditis elegans and Drosophila, the questions of how ROS regulate aging in higher organisms, and whether they do so to the same extent as in lower organisms, have emerged.

Citation: L. L. Dugan, K. L. Quick, Reactive Oxygen Species and Aging: Evolving Questions. Sci. Aging Knowl. Environ. 2005 (26), pe20 (2005).

Read the Full Text




THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts.
S. Kapeta, N. Chondrogianni, and E. S. Gonos (2010)
J. Biol. Chem. 285, 8171-8184
   Abstract »    Full Text »    PDF »
Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease.
G. P. Sykiotis and D. Bohmann (2010)
Science Signaling 3, re3
   Abstract »    Full Text »    PDF »
Can O2 Dysregulation Induce Premature Aging?.
R. M. Douglas and G. G. Haddad (2008)
Physiology 23, 333-349
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science of Aging Knowledge Environment. ISSN 1539-6150