Sci. Aging Knowl. Environ., 29 June 2005
Vol. 2005, Issue 26, p. pe20
[DOI: 10.1126/sageke.2005.26.pe20]

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Reactive Oxygen Species and Aging: Evolving Questions

Laura L. Dugan, and Kevin L. Quick

The authors are in the Division of General Medicine and Geriatrics in the Department of Medicine at the University of California, San Diego, La Jolla, CA 92093, USA. E-mail: ladugan{at}ucsd.edu (L.L.D.)

http://sageke.sciencemag.org/cgi/content/full/2005/26/pe20

Key Words: reactive oxygen species • oxidative damage • mitochondria • superoxide dismutase mimetic • calorie restriction • Sir2

Abstract: Over the past 50 years, reactive oxygen species (ROS) have been investigated as putative mediators of the process of aging. As specific genes and pathways that are involved with ROS homeostasis have been linked to aging in lower organisms, such as Caenorhabditis elegans and Drosophila, the questions of how ROS regulate aging in higher organisms, and whether they do so to the same extent as in lower organisms, have emerged.

Citation: L. L. Dugan, K. L. Quick, Reactive Oxygen Species and Aging: Evolving Questions. Sci. Aging Knowl. Environ. 2005 (26), pe20 (2005).

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