|
|
Sci. Aging Knowl. Environ., 20 July 2005 PERSPECTIVESAllelic Variation and Human LongevityAlmut Nebel, and Stefan Schreiber The authors are at the Institute for Clinical Molecular Biology, University Hospital of the Christian-Albrechts-University, 24105 Kiel, Germany, E-mail: s.schreiber{at}mucosa.de (S.S.) http://sageke.sciencemag.org/cgi/content/full/2005/29/pe23Key Words: human longevity • healthy aging • allelic variation • linkage analysis • case-control association studies
Abstract: Human longevity is a complex phenotype with a strong genetic contribution. The search for allelic variation that impacts on longevity often involves population-based association studies of long-lived individuals (centenarians and nonagenarians) and younger controls. A major methodological problem with this approach is that the cases and controls in these experiments are often born several generations apart. The inherent absence of "age matching" can lead to serious misinterpretations. For example, allele frequency differences between long-lived individuals and younger controls may not reflect an effect on longevity but rather a change in population structure over time or different gene-environment interactions across generations. Citation: A. Nebel, S. Schreiber, Allelic Variation and Human Longevity. Sci. Aging Knowl. Environ. 2005 (29), pe23 (2005).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
|
Science of Aging Knowledge Environment. ISSN 1539-6150
News | Science Journals | Careers | Blogs and Communities | Multimedia | Collections | Help | Site Map | RSS
Subscribe | Feedback | Privacy / Legal | About Us | Advertise With Us | Contact Us
© 2005 American Association for the Advancement of Science. All Rights Reserved.
AAAS is a partner of HINARI, AGORA, OARE, eIFL, PatientInform, CrossRef, and COUNTER.
You have reached the bottom of the page. Back to top