Sci. Aging Knowl. Environ., 3 August 2005
Vol. 2005, Issue 31, p. nf61
[DOI: 10.1126/sageke.2005.31.nf61]

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Not a Chip off the Old Block

Study identifies unexpected function for mammalian version of yeast longevity protein

Mitch Leslie

http://sageke.sciencemag.org/cgi/content/full/2005/31/nf61

Abstract: Like a headstrong teen who refuses to enter the family accounting business and joins a rock band instead, the mammalian protein SIRT1 breaks with its relatives, according to a new study. SIRT1's kin in yeast promotes cell division, but the protein prods mouse cells to abandon reproduction. The work reveals SIRT1's previously unknown role in handling long-lasting stress.

Citation: M. Leslie, Not a Chip off the Old Block. Sci. Aging Knowl. Environ. 2005 (31), nf61 (2005).

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