Sci. Aging Knowl. Environ., 3 August 2005
Detour to Death
Protein kills cells by diverting electrons and crafting free radicals
R. John Davenporthttp://sageke.sciencemag.org/cgi/content/full/2005/31/nf62
Abstract: Construction signs steer traffic around trouble, but new work reveals a diversion that routes cells into danger. A protein named p66Shc funnels electrons down an unusual path and uses them to make cell-killing compounds instead of energy. The results might help researchers understand why mice without the protein survive unusually well.
Citation: R. J. Davenport, Detour to Death. Sci. Aging Knowl. Environ. 2005 (31), nf62 (2005).
Science of Aging Knowledge Environment. ISSN 1539-6150