Sci. Aging Knowl. Environ., 3 August 2005
Vol. 2005, Issue 31, p. nf62
[DOI: 10.1126/sageke.2005.31.nf62]

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Detour to Death

Protein kills cells by diverting electrons and crafting free radicals

R. John Davenport

http://sageke.sciencemag.org/cgi/content/full/2005/31/nf62

Abstract: Construction signs steer traffic around trouble, but new work reveals a diversion that routes cells into danger. A protein named p66Shc funnels electrons down an unusual path and uses them to make cell-killing compounds instead of energy. The results might help researchers understand why mice without the protein survive unusually well.

Citation: R. J. Davenport, Detour to Death. Sci. Aging Knowl. Environ. 2005 (31), nf62 (2005).

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