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Sci. Aging Knowl. Environ., 3 August 2005
Vol. 2005, Issue 31, p. pe24
[DOI: 10.1126/sageke.2005.31.pe24]

PERSPECTIVES

From Bedside to Bench: Research Agenda for Frailty

Linda P. Fried, Evan C. Hadley, Jeremy D. Walston, Anne B. Newman, Jack M. Guralnik, Stephanie Studenski, Tamara B. Harris, William B. Ershler, and Luigi Ferrucci

The authors are at the Center on Aging and Health and the Division of Geriatric Medicine and Gerontology at the Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA (L.P.F. and J.D.W.), the National Institute on Aging, Bethesda, MD 20892, USA (E.C.H.), the Division of Geriatric Medicine at the University of Pittsburgh, Pittsburgh, PA 15213, USA (A.N. and S.S.), the Laboratory of Epidemiology, Demography, and Biometry at the National Institute on Aging, Bethesda, MD 20814, USA (J.M.G. and T.B.H.), the Institute for Advanced Studies in Aging and Geriatric Medicine, Washington, DC 20007, USA (W.B.E.), and the Clinical Research Branch of the National Institute on Aging, Baltimore, MD 21225, USA (L.F.). E-mail: lfried@jhmi.edu (L.P.F.)

http://sageke.sciencemag.org/cgi/content/full/2005/31/pe24

Key Words: frailty • inflammatory cytokines • stressors • loss of complexity • loss of redundancy • systems biology

Abstract: The American Geriatrics Society sponsored a working conference in January 2004, funded by the National Institute on Aging, to establish the state of the art in frailty research and to set a research agenda for the future. The invited participants included senior basic biologists, epidemiologists, geneticists, and clinical investigators who study aging-related issues. This article summarizes the central theoretical observations on frailty and research needs and opportunities presented and discussed at this conference, and lays out an agenda for future research on frailty.

Citation: L. P. Fried, E. C. Hadley, J. D. Walston, A. B. Newman, J. M. Guralnik, S. Studenski, T. B. Harris, W. B. Ershler, L. Ferrucci, From Bedside to Bench: Research Agenda for Frailty. Sci. Aging Knowl. Environ. 2005 (31), pe24 (2005).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nonlinear Multisystem Physiological Dysregulation Associated With Frailty in Older Women: Implications for Etiology and Treatment.
L. P. Fried, Q.-L. Xue, A. R. Cappola, L. Ferrucci, P. Chaves, R. Varadhan, J. M. Guralnik, S. X. Leng, R. D. Semba, J. D. Walston, et al. (2009)
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Frailty Among Community-Dwelling Elderly People in France: The Three-City Study.
J. A. Avila-Funes, C. Helmer, H. Amieva, P. Barberger-Gateau, M. L. Goff, K. Ritchie, F. Portet, I. Carriere, B. Tavernier, L. M. Gutierrez-Robledo, et al. (2008)
J. Gerontol. A Biol. Sci. Med. Sci. 63, 1089-1096
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HIV-1 Infection Is Associated With an Earlier Occurrence of a Phenotype Related to Frailty.
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J. Gerontol. A Biol. Sci. Med. Sci. 62, 1279-1286
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Insulin Resistance and Inflammation as Precursors of Frailty: The Cardiovascular Health Study.
J. I. Barzilay, C. Blaum, T. Moore, Q. Li Xue, C. H. Hirsch, J. D. Walston, and L. P. Fried (2007)
Arch Intern Med 167, 635-641
   Abstract »    Full Text »    PDF »
Elder Mistreatment: Risk, Vulnerability, and Early Mortality.
M. W. Baker (2007)
Journal of the American Psychiatric Nurses Association 12, 313-321
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