Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. Aging Knowl. Environ., 17 August 2005
Vol. 2005, Issue 33, p. pe25
[DOI: 10.1126/sageke.2005.33.pe25]

PERSPECTIVES

Making Young Tumors Old: A New Weapon Against Cancer?

Julien Sage

The author is at Stanford University School of Medicine, Stanford CA 94305, USA. E-mail: julsage{at}stanford.edu.

http://sageke.sciencemag.org/cgi/content/full/2005/33/pe25

Key Words: senescence • cancer • tumor • oncogene • p53 • Ras

Abstract: As the population of industrial nations ages, the incidence of cancer and cancer mortality is increasing. Intuitively, older organisms may be less able to cope with accumulated damage and thus be more prone to develop cancer. However, so far, the links between aging and cancer have been only partially explored. Strikingly, four recent studies now indicate that premature senescence accompanied by cell cycle arrest occurs in tumors initiated by an oncogenic mutation. Thus, senescence may act as a key tumor suppressor mechanism in young tumors in vivo.

Citation: J. Sage, Making Young Tumors Old: A New Weapon Against Cancer? Sci. Aging Knowl. Environ. 2005 (33), pe25 (2005).

Read the Full Text




THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cancer Suppression at Old Age.
C. Harding, F. Pompei, E. E. Lee, and R. Wilson (2008)
Cancer Res. 68, 4465-4478
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT

To Advertise     Find Products

Science of Aging Knowledge Environment. ISSN 1539-6150