Sci. Aging Knowl. Environ., 24 August 2005
Vol. 2005, Issue 34, p. nf68
[DOI: 10.1126/sageke.2005.34.nf68]


Family Feud

Protein relative of p53 has opposite influence on aging

R. John Davenport

Abstract: Siblings sometimes have contrasting personalities despite similar appearances. The tumor-preventing molecule p53 accelerates aging, but new results suggest that a related protein retards it. Mice without the protein, called p63, age unusually quickly, and their cells divide sluggishly. The findings bolster the notion that dwindling stem cell stores promote physical deterioration.

Citation: R. J. Davenport, Family Feud. Sci. Aging Knowl. Environ. 2005 (34), nf68 (2005).

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