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Sci. Aging Knowl. Environ., 31 August 2005
Vol. 2005, Issue 35, p. pe26
[DOI: 10.1126/sageke.2005.35.pe26]


Interfering with Longevity

Siu Sylvia Lee

The author is in the Department of Molecular Biology and Genetics at Cornell University, Ithaca, NY 14850, USA. E-mail:SSL29{at}

Key Words: RNA interference • RNAi screen • C. elegansdaf-2daf-16 • mitochondria

Abstract: Several recent studies have highlighted how RNA interference has advanced aging-related research in Caenorhabditis elegans. Two new genome-wide RNAi-based screens together identified more than 100 new candidate longevity genes. RNAi has also greatly facilitated the functional validation of several large-scale gene expression profiling studies. Furthermore, RNAi is flexible and can be administered at different times throughout life; this feature has been exploited to analyze the temporal requirement of genes in life-span determination.

Citation: S. S. Lee, Interfering with Longevity. Sci. Aging Knowl. Environ. 2005 (35), pe26 (2005).

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