Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Aging Knowl. Environ., 26 January 2005
Vol. 2005, Issue 4, p. pe3
[DOI: 10.1126/sageke.2005.4.pe3]

PERSPECTIVES

Apoptotic Killing of Fibroblasts by Matrix-Bound Advanced Glycation Endproducts

Mark E. Obrenovich, and Vincent M. Monnier

The authors are in the Department of Pathology at Case Western Reserve University, Cleveland, OH 44106, USA. E-mail: vmm3{at}cwru.edu (V.M.M.)

http://sageke.sciencemag.org/cgi/content/full/2005/4/pe3

Key Words: extracellular matrix • skin • advanced glycation endproduct • RAGE • apoptosis • diabetes • cancer

Abstract: The extracellular matrix accumulates biologically active advanced glycation endproducts such as carboxymethyl-lysine (CML). Alikhani et al. recently reported that CML-rich collagen, representing an artifically aged matrix protein, induces apoptosis in vivo and in fibroblasts. This observation may have profound implications for the biology of cell-matrix interactions during aging.

Citation: M. E. Obrenovich, V. M. Monnier, Apoptotic Killing of Fibroblasts by Matrix-Bound Advanced Glycation Endproducts. Sci. Aging Knowl. Environ. 2005 (4), pe3 (2005).

Read the Full Text




THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.
M. Volkmar, S. Dedeurwaerder, D. A. Cunha, M. N. Ndlovu, M. Defrance, R. Deplus, E. Calonne, U. Volkmar, M. Igoillo-Esteve, N. Naamane, et al. (2012)
EMBO J. 31, 1405-1426
   Abstract »    Full Text »    PDF »
Non-enzymatic Glycation of Bone Collagen Modifies Osteoclastic Activity and Differentiation.
U. Valcourt, B. Merle, E. Gineyts, S. Viguet-Carrin, P. D. Delmas, and P. Garnero (2007)
J. Biol. Chem. 282, 5691-5703
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science of Aging Knowledge Environment. ISSN 1539-6150