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Sci. Aging Knowl. Environ., 26 January 2005
Vol. 2005, Issue 4, p. pe3
[DOI: 10.1126/sageke.2005.4.pe3]


Apoptotic Killing of Fibroblasts by Matrix-Bound Advanced Glycation Endproducts

Mark E. Obrenovich, and Vincent M. Monnier

The authors are in the Department of Pathology at Case Western Reserve University, Cleveland, OH 44106, USA. E-mail: vmm3{at} (V.M.M.)

Key Words: extracellular matrix • skin • advanced glycation endproduct • RAGE • apoptosis • diabetes • cancer

Abstract: The extracellular matrix accumulates biologically active advanced glycation endproducts such as carboxymethyl-lysine (CML). Alikhani et al. recently reported that CML-rich collagen, representing an artifically aged matrix protein, induces apoptosis in vivo and in fibroblasts. This observation may have profound implications for the biology of cell-matrix interactions during aging.

Citation: M. E. Obrenovich, V. M. Monnier, Apoptotic Killing of Fibroblasts by Matrix-Bound Advanced Glycation Endproducts. Sci. Aging Knowl. Environ. 2005 (4), pe3 (2005).

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