Sci. Aging Knowl. Environ., 19 October 2005
Vol. 2005, Issue 42, p. or15


Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

Enzo Nisoli, Cristina Tonello, Annalisa Cardile, Valeria Cozzi, Renata Bracale, Laura Tedesco, Sestina Falcone, Alessandra Valerio, Orazio Cantoni, Emilio Clementi, Salvador Moncada, and Michele O. Carruba

Abstract: Science 310, 314-317 (2005).

Calorie restriction extends life span in organisms ranging from yeast to mammals. Here, we report that calorie restriction for either 3 or 12 months induced endothelial nitric oxide synthase (eNOS) expression and 3',5'-cyclic guanosine monophosphate formation in various tissues of male mice. This was accompanied by mitochondrial biogenesis, with increased oxygen consumption and adenosine triphosphate production, and an enhanced expression of sirtuin 1. These effects were strongly attenuated in eNOS null-mutant mice. Thus, nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals.

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Science of Aging Knowledge Environment. ISSN 1539-6150