Sci. Aging Knowl. Environ., 9 November 2005
Vol. 2005, Issue 45, p. nf85
[DOI: 10.1126/sageke.2005.45.nf85]

NEWS FOCUS

Cancer Connection

Tumor-fighter throttles life-extending protein SIRT1

Mitch Leslie

http://sageke.sciencemag.org/cgi/content/full/2005/45/nf85

Abstract: Cancer and long life seem mutually exclusive, but a new study suggests that a life-extending enzyme also hikes tumor risk. Researchers knew that the enzyme, SIRT1, stalls a pathway that causes abnormal cells to commit suicide. The new work pinpoints a protein that normally keeps SIRT1 under control, but whose production wanes with age.

Citation: M. Leslie, Cancer Connection. Sci. Aging Knowl. Environ. 2005 (45), nf85 (2005).

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