Sci. Aging Knowl. Environ., 16 November 2005
Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake
Jian V. Zhang, Pei-Gen Ren, Orna Avsian-Kretchmer, Ching-Wei Luo, Rami Rauch, Cynthia Klein, and Aaron J. W. Hsuehhttp://sageke.sciencemag.org/cgi/content/abstract/2005/46/or18
Abstract: Science 310, 996-999 (2005).
Ghrelin, a circulating appetite-inducing hormone, is derived from a prohormone by posttranslational processing. On the basis of the bioinformatic prediction that another peptide also derived from proghrelin exists, we isolated a hormone from rat stomach and named it obestatin--a contraction of obese, from the Latin "obedere," meaning to devour, and "statin," denoting suppression. Contrary to the appetite-stimulating effects of ghrelin, treatment of rats with obestatin suppressed food intake, inhibited jejunal contraction, and decreased body-weight gain. Obestatin bound to the orphan G protein-coupled receptor GPR39. Thus, two peptide hormones with opposing action in weight regulation are derived from the same ghrelin gene. After differential modification, these hormones activate distinct receptors.
Science of Aging Knowledge Environment. ISSN 1539-6150