Sci. Aging Knowl. Environ., 23 November 2005
Twists in the Tale of the Aging Yeast
Abstract: Science 310, 1124-1125 (2005).
Aging limits the number of divisions available to cells and the chronological life span of nondividing cells. In his Perspective, Rine discusses recent findings that caloric restriction, SIR2, and its molecular cousins play conserved roles in aging. However, expectations of a simple unified model linking caloric restriction and aging through Sir2 protein's NAD+ cofactor are now on hold.
Science of Aging Knowledge Environment. ISSN 1539-6150