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Sci. Aging Knowl. Environ., 30 November 2005
Vol. 2005, Issue 48, p. pe37
[DOI: 10.1126/sageke.2005.48.pe37]


T Cell Immunity and Aging

Sven Dominik Koch, Juergen Kempf, and Graham Pawelec

The authors are at the Center for Medical Research at the University of Tuebingen, D-72072 Tuebingen, Germany. E-mail: sven-dominik.koch{at} (S.D.K.), graham.pawelec{at} (G.P.)

Key Words: immunosenescence • heat shock protein • p53 polymorphism • chronic antigenic stimulation • cytomegalovirus • DNA damage and repair

Abstract: The effect of age on the immune system is generally detrimental and results in "immunosenescence," a poorly-defined state inadequately reflected in clinical data and for which few reliable "biomarkers of aging" are available. The multinational consortium "T-Cell Immunity in Ageing," T-CIA, was set up to examine these issues specifically as applied to T lymphocytes. This Perspective discusses some of the outcomes of a recent conference that considered progress toward resolving these questions in humans.

Citation: S. D. Koch, J. Kempf, G. Pawelec, T Cell Immunity and Aging. Sci. Aging Knowl. Environ. 2005 (48), pe37 (2005).

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