Sci. Aging Knowl. Environ., 14 December 2005
Increase in Activity During Calorie Restriction Requires Sirt1
Danica Chen, Andrew D. Steele, Susan Lindquist, and Leonard Guarentehttp://sageke.sciencemag.org/cgi/content/abstract/2005/50/or22
Abstract: Science 310, 1641 (2005).
Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here, we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.
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