Sci. Aging Knowl. Environ., 14 December 2005
Vol. 2005, Issue 50, p. or22


Increase in Activity During Calorie Restriction Requires Sirt1

Danica Chen, Andrew D. Steele, Susan Lindquist, and Leonard Guarente

Abstract: Science 310, 1641 (2005).

Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here, we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.

[Abstract/Full Text]

Science of Aging Knowledge Environment. ISSN 1539-6150