Sci. Aging Knowl. Environ., 21 December 2005
Vol. 2005, Issue 51, p. nf91
[DOI: 10.1126/sageke.2005.51.nf91]

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Loose Chromosomes Sink Cells

Gene-silencing mechanism falters in patients with premature aging disorder

Mitch Leslie

http://sageke.sciencemag.org/cgi/content/full/2005/51/nf91

Abstract: "Just relax" might be good advice for stressed-out holiday travelers, but it could be disastrous for chromosomes, according to work presented at the American Society for Cell Biology meeting in San Francisco, California, on 13 December. The study suggests that chromosomes uncoil somewhat in patients with a disease that resembles premature aging, an alteration that could unleash genes whose products aren't needed.

Citation: M. Leslie, Loose Chromosomes Sink Cells. Sci. Aging Knowl. Environ. 2005 (51), nf91 (2005).

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