Sci. Aging Knowl. Environ., 16 February 2005
Vol. 2005, Issue 7, p. re2
[DOI: 10.1126/sageke.2005.7.re2]


More Is Less: Neurogenesis and Age-Related Cognitive Decline in Long-Evans Rats

Jennifer L. Bizon, and Michela Gallagher

The authors are in the Department of Psychology, Texas A&M University, College Station, TX 77843-4235, USA (J.L.B.) and the Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA (M.G.). E-mail: jbizon{at} (J.L.B.)

Key Words: cognitive impairment • hippocampus • memory loss • neurogenesis • rat model • water maze

Abstract: A reduction in the ability to generate new neurons in the brain has been suggested to contribute to cognitive decline with advanced age. In an outbred model strain of Long-Evans rats, cognitive performance as a function of age is variable in assessments of hippocampal-dependent spatial memory. Recent research indicates that greater hippocampal neurogenesis accompanies diminished cognitive abilities in older Long-Evans rats. These findings imply that the role of neurogenesis might change between youth and old age, and that further work is needed to understand the potential benefits and liabilities that new neurons may afford an aging brain.

Citation: J. L. Bizon, M. Gallagher, More Is Less: Neurogenesis and Age-Related Cognitive Decline in Long-Evans Rats. Sci. Aging Knowl. Environ. 2005 (7), re2 (2005).

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