Sci. Aging Knowl. Environ., 23 February 2005
Vol. 2005, Issue 8, p. nf15
[DOI: 10.1126/sageke.2005.8.nf15]


Stiff Competition

Protein keeps joints from seizing up

R. John Davenport

Abstract: A downhill racer needs a good wax to keep her skis gliding, and her knees also need lubrication. A new study of mice shows how one protein keeps joints such as the knee flexible. Without it, certain cells grow beyond their usual boundaries, causing cartilage to deteriorate and joints to stiffen. Mutations in the gene for this protein underlie a rare human disease, and more subtle changes might contribute to arthritis.

Citation: R. J. Davenport, Stiff Competition. Sci. Aging Knowl. Environ. 2005 (8), nf15 (2005).

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