Sci. Aging Knowl. Environ., 2 March 2005
Vol. 2005, Issue 9, p. re3
[DOI: 10.1126/sageke.2005.9.re3]


Oxidative Mutagenesis, Mismatch Repair, and Aging

Amy M. Skinner, and Mitchell S. Turker

Amy M. Skinner and Mitchell S. Turker are at the Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, Portland, OR 97239, USA. Amy M. Skinner is also in the Department of Environmental and Molecular Toxicology at Oregon State University, Corvallis, OR 97331, USA. Mitchell S. Turker is also in the Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA. E-mail: turkerm{at} (M.S.T.)

Key Words: oxidative stress • oxidative mutagenesis • reactive oxygen species • mismatch repair • cancer

Abstract: A PubMed search for the term "oxidative stress" yields over 29,000 articles published on the subject over the past 10 years; more than 2000 of these articles also include the term "aging" in their title or abstract. Many theories of aging predict causal roles for oxidative stress in the myriad of pathological changes that occur as a function of age, including an increasing propensity to develop cancer. A possible link between aging and cancer is the induction and accumulation of somatic mutations caused by oxidative stress. This Review focuses on small mutational events that are induced by oxidative stress and the role of mismatch repair (MMR) in preventing their formation. It also discusses a possible inhibitory effect of oxidative stress on MMR. We speculate that a synergistic interaction between oxidative damage to DNA and reduced MMR levels will, in part, account for an accumulation of small mutational events, and hence cancer, with aging.

Citation: A. M. Skinner, M. S. Turker, Oxidative Mutagenesis, Mismatch Repair, and Aging. Sci. Aging Knowl. Environ. 2005 (9), re3 (2005).

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Science of Aging Knowledge Environment. ISSN 1539-6150