Sci. Aging Knowl. Environ., 4 January 2006
A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans
Michelle Boehm, and Frank Slackhttp://sageke.sciencemag.org/cgi/content/abstract/2006/1/or2
Abstract: Science 310, 1954-1957 (2005).
The microRNA lin-4 and its target, the putative transcription factor lin-14, control the timing of larval development in Caenorhabditis elegans. Here, we report that lin-4 and lin-14 also regulate life span in the adult. Reducing the activity of lin-4 shortened life span and accelerated tissue aging, whereas overexpressing lin-4 or reducing the activity of lin-14 extended life span. Life-span extension conferred by a reduction in lin-14 was dependent on the DAF-16 and HSF-1 transcription factors, suggesting that the lin-4-lin-14 pair affects life span through the insulin/insulin-like growth factor-1 pathway. This work reveals a role for microRNAs and developmental timing genes in life-span regulation.
Science of Aging Knowledge Environment. ISSN 1539-6150