Sci. Aging Knowl. Environ., 4 January 2006
Inducible Nitric Oxide Synthase Binds, S-Nitrosylates, and Activates Cyclooxygenase-2
Sangwon F. Kim, Daniel A. Huri, and Solomon H. Snyderhttp://sageke.sciencemag.org/cgi/content/abstract/2006/1/or3
Abstract: Science 310, 1966-1970 (2005).
Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs.
Science of Aging Knowledge Environment. ISSN 1539-6150