Sci. Aging Knowl. Environ., 4 January 2006
Vol. 2006, Issue 1, p. or3


Inducible Nitric Oxide Synthase Binds, S-Nitrosylates, and Activates Cyclooxygenase-2

Sangwon F. Kim, Daniel A. Huri, and Solomon H. Snyder

Abstract: Science 310, 1966-1970 (2005).

Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs.

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Science of Aging Knowledge Environment. ISSN 1539-6150