Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. Aging Knowl. Environ., 28 June 2006
Vol. 2006, Issue 10, p. cp1


Mutation selection and the natural history of cancer

John Cairns

Abstract: Survival of the rapidly renewing tissues of long-lived animals like man requires that they be protected against the natural selection of fitter variant cells (that is, the spontaneous appearance of cancer). This article discusses three possible protective mechanisms and shows how they could explain various features of the natural history of certain common cancers of man.

Reproduced by permission.

J. Cairns, Mutation selection and the natural history of cancer. Nature 255, 197-200 (1975).

Citation: J. Cairns, Mutation selection and the natural history of cancer. Sci. Aging Knowl. Environ. 2006 (10), cp1 (2006).

TrAp: a tree approach for fingerprinting subclonal tumor composition.
F. Strino, F. Parisi, M. Micsinai, and Y. Kluger (2013)
Nucleic Acids Res. 41, e165
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science of Aging Knowledge Environment. ISSN 1539-6150