Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Aging Knowl. Environ., 28 June 2006
Vol. 2006, Issue 10, p. dn1
[DOI: 10.1126/sageke.2006.10.dn1]

NEURODEGENERATIVE DISEASE CASE STUDIES

Dementia with Cerebrovascular Disease

Clinton B. Wright, Jean Paul G. Vonsattel, Karen Bell, and Lawrence S. Honig

The authors are at Columbia University College of Physicians and Surgeons, in the Departments of Neurology (C.B.W., K.B., L.S.H.) and Pathology (J.P.G.V.), and in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (K.B., J.P.G.V., L.S.H.) and the Gertrude H. Sergievsky Center (K.B., L.S.H.), New York, NY 10032, USA. E-mail: CWright{at}neuro.columbia.edu (C.B.W.); lh456{at}columbia.edu (L.S.H.)

http://sageke.sciencemag.org/cgi/content/full/2006/10/dn1

Key Words: Alzheimer's disease • cerebrovascular disease • stroke • dementia • subcortical arteriosclerotic encephalopathy

Abstract: In this case study, we review the symptoms, cognitive testing, brain imaging, and brain pathology of a woman with dementia, for whom the neuropathological findings suggest a prominent contribution of cerebrovascular disease. Vascular dementia is the term commonly used for persons with dementia resulting from strokes, either clinically evident or subclinical "silent" events. "Mixed dementia" is the term used when there is an admixture of pathological findings related to Alzheimer's disease (AD) and cerebrovascular disease, as in this situation. In some cases of mixed dementia, the pathological involvement of AD may be the principal contributory cause of the cognitive symptoms, and in others, the vascular changes may give the greater contribution.

Citation: C. B. Wright, J. P. G. Vonsattel, K. Bell, L. S. Honig, Dementia with Cerebrovascular Disease. Sci. Aging Knowl. Environ. 2006 (10), dn1 (2006).

Read the Full Text







To Advertise     Find Products


Science of Aging Knowledge Environment. ISSN 1539-6150