Sci. Aging Knowl. Environ., 28 June 2006
Vol. 2006, Issue 10, p. or12


Checkpoint Proteins Control Survival of the Postmitotic Cells in Caenorhabditis elegans

Anders Olsen, Maithili C. Vantipalli, and Gordon J. Lithgow

Abstract: Science 312, 1381-1385 (2006).

Checkpoints are evolutionarily conserved signaling mechanisms that arrest cell division and alter cellular stress resistance in response to DNA damage or stalled replication forks. To study the consequences of loss of checkpoint functions in whole animals, checkpoint genes were inactivated in the nematode C. elegans. We show that checkpoint proteins are not only essential for normal development but also determine adult somatic maintenance. Checkpoint proteins play a role in the survival of postmitotic adult cells.

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Science of Aging Knowledge Environment. ISSN 1539-6150