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Sci. Aging Knowl. Environ., 28 June 2006
Vol. 2006, Issue 10, p. pe19
[DOI: 10.1126/sageke.2006.10.pe19]


A Work in Progress: The Metabolic Syndrome

Jose A. Luchsinger

The author is in the Department of Medicine at Columbia University, New York, NY 10032, USA. E-mail: jal94{at}

Key Words: metabolic syndrome • insulin resistance • vascular risk factors • cardiovascular disease • lifestyle changes

Abstract: Metabolic syndrome refers to a constellation of risk factors for cardiovascular disease. They include elevated plasma glucose concentrations, dyslipidemia, hypertension, and abdominal obesity. These conditions typically occur during middle age or later in life. Although there is no clear consensus on the diagnosis of metabolic syndrome, it is a potentially important entity to recognize and manage once traditional cardiovascular risk factors, such as smoking, hypertension, dyslipidemia, and diabetes, have been treated individually. This Perspective summarizes our current knowledge of the metabolic syndrome. Lifestyle change, including diet and exercise, is probably the best available option for treating the metabolic syndrome. However, rigorous lifestyle interventions are difficult to implement outside of a clinical trial setting, especially among elderly patients.

Citation: J. A. Luchsinger, A Work in Progress: The Metabolic Syndrome. Sci. Aging Knowl. Environ. 2006 (10), pe19 (2006).

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