Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. Aging Knowl. Environ., 8 March 2006
Vol. 2006, Issue 6, p. nf7
[DOI: 10.1126/sageke.2006.6.nf7]


Craving an Answer

After 70 years, researchers might be closing in on how calorie restriction extends life

Mitch Leslie

Abstract: Calorie restriction (CR) tunes up metabolism and makes animals more active. However, the regimen has drawbacks, such as sensitivity to cold and loss of reproduction. Some animals don't gain time, and CR might not work for old individuals. Researchers don't have a full-fledged theory for how CR works, but some scientists postulate that the diet extends life by activating a stress-fighting response. Some researchers argue that we are close to understanding one molecular mechanism behind that effect that involves the enzyme Sir2p. Recent work questions the Sir2p connection and supports an alternative, the TOR pathway. Fat and leaky mitochondria might also play a role in CR. An upcoming study might clarify the diet's benefits for humans.

Citation: M. Leslie, Craving an Answer. Sci. Aging Knowl. Environ. 2006 (6), nf7 (2006).

Read the Full Text

To Advertise     Find Products

Science of Aging Knowledge Environment. ISSN 1539-6150