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Sci. Aging Knowl. Environ., 8 March 2006
Vol. 2006, Issue 6, p. pe7
[DOI: 10.1126/sageke.2006.6.pe7]

PERSPECTIVES

Small-Fiber Neuropathy: Answering the Burning Questions

Ezekiel Fink, and Anne Louise Oaklander

The authors are at the Nerve Injury Unit, a division of the Departments of Anesthesiology, Neurology, and Neuropathology at Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. E-mail: efink{at}partners.org (E.F.)

http://sageke.sciencemag.org/cgi/content/full/2006/6/pe7

Key Words: small-fiber neuropathy • pain • punch skin biopsy • neuralgia • neuropathic pain

Abstract: Small-fiber neuropathy is a peripheral nerve disease that most commonly presents in middle-aged and older people, who develop burning pain in their feet. Although it can be caused by disorders of metabolism such as diabetes, chronic infections (such as with human immunodeficiency virus), genetic abnormalities, toxicity from various drugs, and autoimmune diseases, the cause often remains a mystery because standard electrophysiologic tests for nerve injury do not detect small-fiber function. Inadequate ability to test for and diagnose small-fiber neuropathies has impeded patient care and research, but new tools offer promise. Infrequently, the underlying cause of small-fiber dysfunction is identified and disease-modifying therapy can be instituted. More commonly, the treatments for small-fiber neuropathy involve symptomatic treatment of neuropathic pain.

Citation: E. Fink, A. L. Oaklander, Small-Fiber Neuropathy: Answering the Burning Questions. Sci. Aging Knowl. Environ. 2006 (6), pe7 (2006).

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