Sci. Aging Knowl. Environ., 8 March 2006
Vol. 2006, Issue 6, p. re1
[DOI: 10.1126/sageke.2006.6.re1]

The Development of Amyloid beta Protein Deposits in the Aged Brain

Dietmar R. Thal, Estibaliz Capetillo-Zarate, Kelly Del Tredici, and Heiko Braak

The authors are at the Department of Neuropathology, University of Bonn, D-53105 Bonn, Germany (D.R.T. and E.C.-Z.) and at the Institute for Clinical Neuroanatomy, J. W. Goethe University, D-60590 Frankfurt am Main, Germany (K.D.T. and H.B.). E-mail: Dietmar.Thal{at} (D.R.T.)

Key Words: senile plaques • amyloid beta protein • Alzheimer's disease • tau

Abstract: The deposition of amyloid beta protein (Abeta) in the human brain and the generation of neurofibrillary tangles are the histopathological hallmarks of Alzheimer's disease. Accumulation of Abeta takes place in senile plaques and in cerebrovascular deposits as a result of an imbalance between Abeta production and clearance. This Review describes the different types of Abeta deposits, which can be distinguished by their morphology and by the hierarchical involvement of distinct areas of the brain in Abeta deposition. The role of intracellular Abeta in Abeta deposition and the mechanism of Abeta toxicity are also discussed.

Citation: D. R. Thal, E. Capetillo-Zarate, K. Del Tredici, H. Braak, The Development of Amyloid beta Protein Deposits in the Aged Brain. Sci. Aging Knowl. Environ. 2006 (6), re1 (2006).

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