Sci. Aging Knowl. Environ., 5 April 2006
Vol. 2006, Issue 7, p. nf10
[DOI: 10.1126/sageke.2006.7.nf10]


Tag-Team Recycling

Mechanisms for protein disposal interact

Mitch Leslie

Abstract: Tidying up might take a bulldozer or a sponge, depending on whether the mess is a wrecked building or a spilled can of Coke. Similarly, cells rely on different mechanisms when they need to remove damaged proteins in bulk or one by one. New work suggests that, contrary to conventional wisdom, if one of these mechanisms fails, the other can take over part of its work. The results support the notion that deterioration of a particular cleanup system promotes aging.

Citation: M. Leslie, Tag-Team Recycling. Sci. Aging Knowl. Environ. 2006 (7), nf10 (2006).

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