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Sci. Aging Knowl. Environ., 3 May 2006 PERSPECTIVESToward a Better Understanding of KlothoYo-ichi Nabeshima The author is in the Department of Pathology and Tumor Biology at Kyoto University Graduate School of Medicine, Yoshida Konoe-cho Sakyu-ku, Kyoto 606-8501, Japan. E-mail: nabemr{at}lmls.med.kyoto-u.ac.jp http://sageke.sciencemag.org/cgi/content/full/2006/8/pe11Key Words: Klotho • fibroblast growth factor 23 • premature aging • vitamin D • calcium homeostasis • phosphorus homeostasis • insulin/IGF-1 signaling
Abstract:
klotho mutant mice were originally described as a short-lived mouse model with premature aging-like disorders. The klotho gene responsible for these phenotypes encodes a type I membrane protein with a considerable similarity to Citation: Y.-i. Nabeshima, Toward a Better Understanding of Klotho. Sci. Aging Knowl. Environ. 2006 (8), pe11 (2006).
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-glycosidase. klotho is predominantly expressed in tissues functioning in the regulation of calcium homeostasis. Suggested functions of Klotho are (i) a fundamental regulator of calcium homeostasis, namely, a cofactor for the fibroblast growth factor (FGF) receptor 1c in FGF23 signaling and a regulator of parathyroid hormone secretion; (ii) a hormone that interferes with the intracellular signaling of insulin and insulin-like growth factor-1; and (iii) a 
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