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Sci. Aging Knowl. Environ., 24 May 2006
Vol. 2006, Issue 9, p. pe14
[DOI: 10.1126/sageke.2006.9.pe14]

PERSPECTIVES

Aging at the Interface of Stem Cell Renewal, Apoptosis, Senescence, and Cancer

Almut Nebel, Elke Schaffitzel, and Maren Hertweck

The authors are at the Institute of Clinical Molecular Biology, University of Kiel, Germany (A.N.), the Bio 3, Bioinformatics and Molecular Genetics, University of Freiburg, Germany (E.S. and M.H.), and the Renal Division, University Hospital Freiburg, Germany (E.S.). E-mail: maren.hertweck{at}biologie.uni-freiburg.de

http://sageke.sciencemag.org/cgi/content/full/2006/9/pe14

Key Words: stem cells • systems biology • regulatory pathways and networks • epigenetic modifications

Abstract: The aging-related research field has focused on the detection of genetic factors that affect the aging process, but more recently scientists have started to shift their attention to novel and more integrative ways of studying cellular and organismal function. Such approaches allow them to uncover and explore unexpected patterns and themes, resulting in a more comprehensive knowledge of the complex regulatory pathways and networks involved in aging and age-related diseases. Eventually, this knowledge will lead to a systems-level understanding of aging. The third "Functional Genomics of Aging" conference held in Palermo, Italy, in March/April 2006 highlighted some of the more exciting work in this area.

Citation: A. Nebel, E. Schaffitzel, M. Hertweck, Aging at the Interface of Stem Cell Renewal, Apoptosis, Senescence, and Cancer. Sci. Aging Knowl. Environ. 2006 (9), pe14 (2006).

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Science of Aging Knowledge Environment. ISSN 1539-6150