Sci. Aging Knowl. Environ., 10 October 2001
Vol. 2001, Issue 2, p. or13

OTHER RESOURCES

Do Mitochondrial Mutations Dim the Fire of Life?

Elizabeth Pennisi

http://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/2/or13

Abstract: Science 286, 664 (1999).

A team of geneticists reports some of the first hard evidence that the cellular power plants called mitochondria deteriorate as people age (Science, 22 October 1999, p. 774). The team found that mutations in the 16,500-base mitochondrial genome accumulate with time and in a particularly important region: a 1000-base segment that controls the genome's replication. Although some scientists are not convinced that mitochondrial changes bring about aging by themselves, the new results have researchers on aging taking a fresh look at the mitochondria.

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