Sci. Aging Knowl. Environ., 10 October 2001
DNA Ends RecQ-uire Attention
Leonard Wu, and Ian D. Hicksonhttp://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/2/or17
Abstract: Science 292, 229-230 (2001).
From yeast to flies to humans, cells have evolved a conserved series of proteins that repair breaks in the DNA and maintain the ends of chromosomes (telomeres) at a constant length. The authors discuss the part played by the RecQ helicase family of enzymes in maintaining genome stability and explain how mutations in these proteins result in several rare cancer-susceptibility and premature-aging syndromes.
Science of Aging Knowledge Environment. ISSN 1539-6150