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Sci. Aging Knowl. Environ., 10 October 2001
Vol. 2001, Issue 2, p. or20

OTHER RESOURCES

Dopamine's Reversal of Fortune

Randy D. Blakely

http://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/2/or20

Abstract: Science 293, 2407-2409 (2001).

Dopamine transporters (DATs) are considered to be the janitors of the neurotransmission world, sucking up excess dopamine that has been released into synapses (the gaps between neurons). Not so fast, according to Blakely in his insightful Perspective. It turns out that DATs can be switched into reverse, exporting instead of importing dopamine. This switch may help in dampening down the excitability of dopaminergic neurons that have been overstimulated by the excitatory neurotransmitter glutamate.

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Science of Aging Knowledge Environment. ISSN 1539-6150