Sci. Aging Knowl. Environ., 14 November 2001
Vol. 2001, Issue 7, p. or21

OTHER RESOURCES

Dopamine May Sustain Toxic Protein

Jennifer Couzin

http://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/7/or21

Abstract: Science 294, 1257-1258 (2001).

The symptoms of Parkinson's disease are rooted in the death of neurons that churn out the chemical messenger dopamine, but precisely what kills these brain cells has long stumped researchers. Now a provocative test tube study, reported in the 9 November issue of Science [Abstract/Full Text], suggests that a surprising culprit--dopamine itself--may assist in the neurodegeneration that defines the disease. Parkinson's researchers say the findings are intriguing and worthy of follow-up experiments but caution that they must be confirmed in cell cultures and laboratory animals.

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