Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Careers Booklet

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. Aging Knowl. Environ., 13 March 2002
Vol. 2002, Issue 10, p. or3

OTHER RESOURCES

Redox Regulation of Forkhead Proteins Through a p66shc-Dependent Signaling Pathway

Shino Nemoto, and Toren Finkel

http://sageke.sciencemag.org/cgi/content/abstract/sageke;2002/10/or3

Abstract: Science 7 March 2002 (10.1126/science.1069004) (Science Express Reports)

Genetic determinants of longevity include the forkhead related transcription factor DAF-16 in the worm Caenorhabditis elegans and the p66shc locus in mice. We demonstrate that in mammalian cells, p66shc regulates intracellular oxidant levels and that hydrogen peroxide can negatively regulate forkhead activity. In p66shc-/- cells, the activity of the mammalian forkhead homologue FKHRL1 is increased and redox-dependent forkhead inactivation is reduced. In addition, expression of FKHRL1 results in an increase in both hydrogen peroxide scavenging and oxidative stress resistance. These results demonstrate an important functional relationship between three distinct elements linked to aging, forkhead proteins, p66shc, and intracellular oxidants.

Abstract/PDF

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science of Aging Knowledge Environment. ISSN 1539-6150