Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Sci. Aging Knowl. Environ., 23 January 2002
Vol. 2002, Issue 3, p. or2

OTHER RESOURCES

Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans

Nuno Arantes-Oliveira, Javier Apfeld, Andrew Dillin, and Cynthia Kenyon

http://sageke.sciencemag.org/cgi/content/abstract/sageke;2002/3/or2

Abstract: Science 295, 502-505 (2002).

The germ line of the nematode Caenorhabditis elegans influences life-span; when the germ-line precursor cells are removed, life-span is increased dramatically. We find that neither sperm, nor oocytes, nor meiotic precursor cells are responsible for this effect. Rather life-span is influenced by the proliferating germ-line stem cells. These cells, as well as a downstream transcriptional regulator, act in the adult to influence aging, indicating that the aging process remains plastic during adulthood. We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity.

Full Text

To Advertise     Find Products

Science of Aging Knowledge Environment. ISSN 1539-6150