Sci. Aging Knowl. Environ., 7 August 2002
Vol. 2002, Issue 31, p. pe12
[DOI: 10.1126/sageke.2002.31.pe12]


Mitochondrial Bioenergetics, Aging, and Aging-Related Disease

David Nicholls

The author is at the Buck Institute for Age Research, Novato, CA 94945, USA. E-mail:;2002/31/pe12

Key Words: mitochondria • bioenergetics • antioxidants • reactive oxygen species • neurodegeneration • neurodegenerative disease

Abstract: In this Perspective, the author discusses some of the bioenergetic consequences of the various alterations in mitochondrial function that have been hypothesized to be associated with human aging and aging-related disease. Special focus is afforded to neurodegenerative disease.

Citation: D. Nicholls, Mitochondrial Bioenergetics, Aging, and Aging-Related Disease. Science's SAGE KE (7 August 2002),;2002/31/pe12

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