Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. Aging Knowl. Environ., 25 June 2003
Vol. 2003, Issue 25, p. or9

OTHER RESOURCES

Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens

Danielle A. Garsin, Jacinto M. Villanueva, Jakob Begun, Dennis H. Kim, Costi D. Sifri, Stephen B. Calderwood, Gary Ruvkun, and Frederick M. Ausubel

http://sageke.sciencemag.org/cgi/content/abstract/sageke;2003/25/or9

Abstract: Science 300, 1921 (2003).

Aging is known to be associated with an increased susceptibility to infectious disease. The insulin/insulin-like growth factor 1 (IGF-1) signaling pathway has been shown to affect the rate of aging in a number of organisms. In this Brevia, Garsin et al. show that insulin/IGF-1 signaling influences Caenorhabditis elegans resistance to bacteria, such that long-lived worms are slow to succumb to infection. These results suggest that enhanced immunity is a feature of genetically determined longevity.

Abstract/PDF

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science of Aging Knowledge Environment. ISSN 1539-6150