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Sci. Aging Knowl. Environ., 8 October 2003
Vol. 2003, Issue 40, p. pe28
[DOI: 10.1126/sageke.2003.40.pe28]

PERSPECTIVES

Reducing Integrins Improves the Quality of Fly Life

Catherine N. Torgler, and Nicholas H. Brown

The authors are in the Wellcome Trust/Cancer Research UK Institute and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, UK. E-mail: cnt20{at}mole.bio.cam.ac.uk

http://sageke.sciencemag.org/cgi/content/full/sageke;2003/40/pe28

Key Words: integrin • mobility • Drosophila • stress

Abstract: Integrins are cell surface receptors that mediate adhesion to the extracellular matrix. In this Perspective, we focus on the recent finding that a decrease in the levels of integrins yields fruit flies that retain youthful mobility as they age and display an increased mean life span. We discuss how the reduction of integrin activity might lead to the observed changes.

Citation: C. N. Torgler, N. H. Brown, Reducing Integrins Improves the Quality of Fly Life. Sci. SAGE KE 2003 (40), pe28 (2003).

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Science of Aging Knowledge Environment. ISSN 1539-6150