Sci. Aging Knowl. Environ., 5 November 2003
Stem cells in the gut pile up mutations in mitochondrial DNA
R. John Davenporthttp://sageke.sciencemag.org/cgi/content/full/sageke;2003/44/nw150
Key Words: cytochrome c oxidase succinate dehydrogenase heteroplasmy homoplasmy
Abstract: Dark crypts swarming with cloned mutants: It's not the premise for a grade B horror film but the result of a new study. The work is the first to reveal that intestinal stem cells amass DNA mutations in their mitochondria, and it raises the possibility that the accumulation of such defects as we age could choke stem cells.
Citation: R. J. Davenport, Crypt-ic Message. Sci. Aging Knowl. Environ. 2003 (44), nw150 (2003).
Science of Aging Knowledge Environment. ISSN 1539-6150